Degenerative Disc Disease

Osteoarthritis of the spine, usually in the neck or lower back. Also called: DDD, degeneration of the intervertebral disc.
What is Degenerative Disc Disease

Degeneration of one or more intervertebral disc(s) of the spine, often called degenerative disc disease or degenerative disc disorder (“DDD”), is a condition that can be painful and can greatly affect the quality of one’s life. Disc degeneration is a disease of aging, and though for most people is not a problem, in certain individuals a degenerated disc can cause severe chronic pain. Unfortunately, approximately 50% of the individuals that undergo expensive surgery have no improvement or, even worse, result in a more painful and debilitating condition than they experienced prior to surgery. Reports suggest 6 to 10 million individuals in the United States suffer from DDD (chronic lower back pain). Annually, in the United States, there are over 800,000 surgeries. Surgeries include lumbar fusions (260,000 cases annually), primary discectomy (350,000 cases annually) and primary decompressions (70,000 cases annually). The expected clinical outcome of surgical treatment for DDD is at best a 60% chance of a 50% improvement in symptoms.

Molecular Prognosis/Diagnosis

There is a tremendous need for a diagnostic to assist individuals and their specialists in determining course of care that will result in better outcomes, in particular to ascertain the likely outcome of a $50,000 invasive procedure with a known low likelihood of success. There is also a significant need for the payers, (e.g. insurance companies) to better determine the risk of the insured population. PRx has secured the exclusive worldwide rights to the intellectual property supporting the DDD Test.